郑以,四川雅安人,西北农林科技大学副教授、硕导。雄性精子专家。
一、研究方向
生殖生物学和干细胞生物学。主要从事雄性生殖相关基础和转化研究,重点研究精子发生和生殖干细胞。
二、教授课程
本科生:《细胞生物学》(双语)
硕士:《动物繁殖理论与生物技术》《动物繁殖生理与胚胎工程》
教授推荐:陈宁博,宁夏西吉人,西北农林科技大学副教授、硕导,牛业专家
三、教育简历
2010.06,四川农业大学,动物科技学院动物科学,农学学士;
2013.06,西北农林科技大学,动物科技学院动物遗传育种与繁殖,农学硕士;
2018.02,荷兰阿姆斯特丹大学,医学院生殖医学与生物学,医学博士。
2018.02,西北农林科技大学,动物科技学院,教学科研。
四、论文(第一/通讯作者)
1、Callista L Mulder#, Yi Zheng#, Sabrina Z Jan, Robert B Struijk, Sjoerd Repping, Geert Hamer, Ans M M van Pelt. Spermatogonial stem cell autotransplantation and germline genomic editing: a future cure for spermatogenic failure and prevention of transmission of genomic diseases. Human Reproduction Update. 2016, 22(5): 561-73. (#共同一作,IF=17.179,中科院1区,Top期刊)
2、Xueni You#, Tianjiao Li#, Youjie Cui, Wei Liu, Zechao Cheng, Wenxian Zeng, Peng Wang, Yi Zheng. Retinoic acid-induced differentiation of porcine prospermatogonia in vitro. Theriogenology. 2023, 198: 344-55. (通讯作者,IF=2.923,中科院2区,Top期刊)
3、Tianjiao Li#, Yi Zheng#, Zhili Wu, Ming Guo, Ruifang Liu, Wenxian Zeng, Yinghua Lv. YTHDF2 controls hexavalent chromium-induced mitophagy through modulating Hif1α and Bnip3 decay via the m6A/mRNA pathway in spermatogonial stem cells/progenitors. Toxicology Letters. 2023, 377: 38-50. (#共同一作,IF=4.271)
4、Yi Zheng#, Lingkai Zhang#, Long Jin#, Pengfei Zhang#, Fuyuan Li, Ming Guo, Qiang Gao, Yao Zeng, Mingzhou Li, Wenxian Zeng. Unraveling three-dimensional chromatin structural dynamics during spermatogonial differentiation. Journal of Biological Chemistry. 2022, 298(2): 101559. (IF=”5.486,中科院2区,自然指数期刊、Top期刊)
5、Yi Zheng#, Qiang Gao#, Tianjiao Li, Ruifang Liu, Zechao Cheng, Ming Guo, Jinhong Xiao, De Wu, Wenxian Zeng. Sertoli cell and spermatogonial development in pigs. Journal of Animal Science and Biotechnology. 2022, 13: 45. (IF=”6.175,中科院1区,Top期刊)
6、Ruifang Liu#, Zidong Liu#, Ming Guo, Wenxian Zeng, Yi Zheng. SETDB1 regulates porcine spermatogonial adhesion and proliferation through modulating MMP3/10 transcription. Cells. 2022, 11(3): 370. (通讯作者,IF=7.666,中科院2区)
7、Tianjiao Li#, Yi Zheng#, Tao Li, Ming Guo, Xiaodong Wu, Ruifang Liu, Qixiang Liu, Xueni You, Wenxian Zeng, Yinghua Lv. Potential dual protective effects of melatonin on spermatogonia against hexavalent chromium. Reproductive Toxicology. 2022, 111: 92-105. (#共同一作,IF=3.421)
8、Zidong Liu#, Qiang Chen#, Xueni You, Xiaodong Wu, Ruifang Liu, Tao Li, Leilei Gao, Xiaoxu Chen, Anmin Lei, Wenxian Zeng, Yi Zheng. Sperm-derived RNAs improve the efficiency of somatic cell nuclear transfer (SCNT) through promoting R-loop formation. Molecular Reproduction and Development. 2022, 89(8): 325-36. (通讯作者,IF=2.812)
9、Yi Zheng, Yuliang Liu, Rong Hou, Keyu Shi, Yijiao Chen, Tongying Feng, Junhui An. Single-cell RNA-sequencing analysis and characterisation of testicular cells in giant panda (Ailuropoda melanoleuca). Reproduction Fertility and Development. 2022, 34(14): 933-43. (IF=”1.973)
10、Lingkai Zhang, Fuyuan Li, Peipei Lei, Ming Guo, Ruifang Liu, Ling Wang, Taiyong Yu, Yinghua Lv, Tao Zhang, Wenxian Zeng, Hongzhao Lu, Yi Zheng. Single-cell RNA-sequencing reveals the dynamic process and novel markers in porcine spermatogenesis. Journal of Animal Science and Biotechnology. 2021, 12: 122. (*通讯作者,IF=6.175,中科院1区,Top期刊)
五、科研项目
1、国家自然科学基金青年项目,32002178,LncRNA-106504875介导ZBTB16调控猪精原干细胞自我更新的分子机制,2021.01-2023.12,24万元,在研,主持
2、陕西省引进国外博士专项,F2020221006,猪精子发生过程中基因组三维结构的动态变化,2021.01-2023.12,22.5万元,在研,主持
3、西北农林科技大学基本科研业务费,DK202104,维甲酸诱导的猪精原干细胞分化与减数分裂进程及其调控网络的构建,2021.06-2022.06,4万元,在研,主持
4、中国博士后科学基金面上项目一等资助,2018M641032,SMC5/6复合物在精原干细胞增殖与分化中的作用及其机制,2019.01-2020.12,8万元,在研,主持
5、陕西省自然科学基础研究计划一般项目(青年),2019JQ-430,SMC5/6复合物维持小鼠精原干细胞基因组稳定性的机制研究,2019.01-2020.12,3万元,结题,主持
6、陕西省高校科协青年人才托举计划项目,20180204,猪精原干细胞增殖与分化关键基因和分子标记的筛选,2019.01-2020.12,1万元,结题,主持
7、畜禽遗传资源发掘与创新利用四川省重点实验室开放课题,SNDK-KF-201804,猪精子发生过程中基因组三维结构的动态变化,2019.01-2020.12,3万元,在研,主持
8、西北农林科技大学博士科研启动基金,2452018037,猪精子发生过程中转录组和染色质动态变化分析,2018.04-2021.02,20万元,结题,主持
六、技术兼职
中国畜牧兽医学会高级会员;
欧洲人类生殖与胚胎学学会(ESHRE)会员;
国际生殖研究学会(SSR)会员;
Frontiers in Genetics主题编辑(Topic Editor);
Frontiers in Endocrinology评审编辑(Review Editor),以及iScience、Theriogenology、Reproduction Fertility and Development、Frontiers in Cell and Developmental Biology等期刊审稿人。
七、联系方式
地址:陕西省咸阳市杨凌区西农路22号西北农林科技大学动物科技学院535办公室
邮箱:y.zheng@nwafu.edu.cn
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