李晓,河北辛集人,西北农林科技大学副教授、博导。中国畜牧兽医学会动物生理学分会会员、动物遗传育种学分会会员,在Frontiers开设Marbling fat in livestock专题,为Frontiers in Cell and Developmental Biology/ Molecular Biosciences/ Genetics/ Veterinary Sciences等杂志组稿。
教授推荐:任刚,河南淮阳人,西北农林科技大学教授,生物遗传专家
一、研究方向
优良猪肉品质形成的生理学和遗传学基础;新型猪生长调节剂的研发和推广;细胞培养肉流程的设计和优化;特色品种遗传多样性调查。
二、教授课程
动物细胞生物学的教学与科研工作,参与细胞生物学精品课程和双语课程的建设。
三、教育简历
2001-2005 本科 南京农业大学动物医学院;
2005-2011 硕博连读 南京农业大学农业部动物生理生化重点开放实验室。
2009.01-2011.01 美国弗吉尼亚理工大学、美国康奈尔大学 合作科研。
2017.11-2018年11 美国华盛顿州立大学 交流访问。
2012.01-至今 西北农林科技大学动物科技学院。
四、科研项目
1、发酵桑叶改良猪胴体品质的应用研究(2019NY-078),陕西省重点研发计划—一般项目,2019-2020,10万元
2、MyHC-AS调控猪骨胳肌II型MyHCs转录的机制研究(31501925),国家自然科学基金青年科学基金项目,2016-2018,19万元(直接经费)
3、PPARγ-AMPK差异性调控猪脂肪沉积的作用机制(2452019205),中央高校基本科研业务费——科技创新一般项目,2019-2020,7万元
4、IGF2-AS调控猪肌肉IGF2启动子活性的分子机制(2014JQ3103),陕西省自然科学基金青年项目,2014-2015,3万元
5、Wnt/β-catenin调节MSTN启动子活性的分子机制(2014M562465),中国博士后科学基金第56批面上资助(二等),2014-2016,5万元
6、伪受体BAMBI在myostatin抑制猪骨骼肌卫星细胞增殖过程中的作用(2014YB005),中央高校基本科研业务费——科技创新一般项目,2014-2016,10万元
7、猪miR-17-92簇启动子克隆及其活性分析(2012BSJJ095),西北农林科技大学博士科研启动基金暨陕西省专项配套经费,2013-2015,10万元
五、论文论著
1、Mingle Dou, Ying Yao, Ying Peng, Meixue Xu, Xin’e Shi, Gongshe Yang, Xiao Li. The long noncoding RNA MyHC IIA/X-AS contributes to skeletal muscle myogenesis and maintains the fast fiber phenotype. Journal of Biological Chemistry, 2020 Apr 10; 295(15):4937-4949, DOI: 10.1074/jbc.RA119.010498
2、Xiaoyu Wang1, Huifang Zhang1, Xin’E Shi, Gongshe Yang, Shiduo Sun, Xiao Li. Elevated miR-10a-5p facilitates cell cycle and restrains adipogenic differentiation via targeting Map2k6 and FASN, respectively. Acta Biochimica et Biophysica Sinica (Shanghai), 2020 May 22 accepted, DOI:10.1093/abbs/gmaa111
3、Xiaoyu Wang, Meixue Xu, Ying Peng, Qimuge Naren, Yanting Xu, Xin Wang, Gongshe Yang, Xin’E Shi, Xiao Li. Triptolide enhances lipolysis of adipocytes by enhancing ATGL transcription via upregulation of p53. Phytotherapy Research, 2020 July 02 online, DOI: 10.1002/ptr.6779
4、Xiaoyu Wang1, Jing Yang1, Ying Yao, Xin’E Shi, Gongshe Yang, Xiao Li. AQP3 facilitates proliferation and adipogenic differentiation of porcine intramuscular adipocytes. Genes, 2020 Apr 22;11(4). pii: E453. doi: 10.3390/genes11040453
5、Lujie Fan, Ying Peng, Dan Wu, Jianhong Hu, Xin’E Shi, Gongshe Yang, Xiao Li. Morus nigra L. leaves improve the meat quality in finishing pigs. Journal of animal physiology and animal nutrition, 2020 Aug 28 online, DOI: 10.1111/jpn.13439
6、Yixin Chu, Ying Yao, Youbo Zhu, Xin’e Shi, Shiduo Sun, Xiao Li. MiR-370 enhances cell cycle and represses lipid accumulation in porcine adipocytes. Animal Biotechnology, 2019, Dec 03; 1-9, doi: 10.1080/10495398.2019.1697278
7、Lujie Fan, Ying Peng, Dan Wu, Jianhong Hu, Xin’e Shi, Gongshe Yang, Xiao Li. Dietary supplementation of Morus nigra L. leaves decrease fat mass partially through elevating leptin-stimulated lipolysis in pig model. Journal of Ethnopharmacology, 2020 Mar 1; 249: 112416. doi.org/10.1016/j.jep.2019.112416
8、Xiao Li, Xing Fu, Gongshe Yang, Min Du. Review: Enhancing intramuscular fat development via targeting fibro-adipogenic progenitor cells in meat animals. Animal, 2020 Feb;14(2):312-321. doi: 10.1017/S175173111900209X
9、武丹,李晓.冷鲜肉保鲜过程中的微生物污染及其预防措施.食品工业科技. 2019, 40 (21):320-325 10、Lujie Fan, Mingle Dou, Xiaoyu Wang, Qichun Han, Bo Zhao, Jianhong Hu, Gongshe Yang, Xin’E Shi, Xiao Li. Fermented corn-soybean meal elevated IGF1 levels in grower-finisher pigs. Journal of Animal Science, 2018, Sep 8th, 96(12): 5144-5151. doi: 10.1093/jas/sky361
11、Xiao Li1, Youbo Zhu1, Huifang Zhang, Guangjun Ma, Guofang Wu, Aoqi Xiang, Xin’E Shi, GongShe Yang, Shiduo Sun. MicroRNA-106a-5p inhibited C2C12 myogenesis via targeting PIK3R1 and modulating the PI3K/AKT signaling. Genes (Basel), 2018, July, 2, 9(7): E333
12、樊路杰, 窦鸣乐, 王小宇, 李泽, 史新娥, 李晓. 宰后肌肉抗氧化能力与肌肉品质的关系. 动物营养学报, 2018, May, 15, 30(5):1676-1680.
13、YouLei Li#, Xiao Li#, TianTuan Jiang, JiaMeng Fan, XueLi Zheng, XinE Shi, TaiY ongYu, GuiYan Chu, GongShe Yang. An additive effect of promoting thermogenic gene expression in mice adipose-derived stromal vascular cells by combination of Rosiglitazone and CL316,243. International Journal of Molecular Science, 2017, 18(5): pii: E1002
14、Xiao Li#, Jing Yang#, Youbo Zhu, Yuan Liu, Xin’e Shi, Gongshe Yang. Maternal high-fat intake dynamically programmed mRNA m6A modifications in adipose and skeletal muscle tissues in offspring. International Journal of Molecular Science, 2016, 17(8): pii: E1336
15、Xiao Li#, Kuilong Huang#, Fenfen Chen, Wanhua Li, Shiduo Sun, Xin-E Shi, Gongshe Yang. Verification of suitable and reliable reference genes for quantitative real-time PCR during adipogenic differentiation in porcine intramuscular stromal-vascular cells. Animal, 2016, 10(6): 947-952
16、Qiangling Zhang, Xin-E Shi, Chengchuang Song, Shiduo Sun, Gongshe Yang, Xiao Li. BAMBI promotes C2C12 myogenic differentiation by enhancing Wnt/β-catenin signaling. International Journal of Molecular Science, 2015, 16(8), 17734-17745
17、Xiao Li#, Jinquan Wang#, Zheng Jiang, Feng Guo, Paul D Soloway, Ruqian Zhao. Role of PRDM16 and its PR domain in the epigenetic regulation of myogenic and adipogenic genes during transdifferentiation of C2C12 cells. Gene. 2015, 570(2), 191-198
18、Chengchuang Song, Guofang Wu, Aoqi Xiang, Qiangling Zhang, Wanhua Li, Gongshe Yang, Shiduo Sun, Xiao Li*. Over-expression of miR-125a-5p inhibits proliferation in C2C12 myoblasts by targeting E2F3. Acta Biochimica et Biophysica Sinica(Shanghai), 2015, 47(4), 244-249
19、Xiao Li#, Li Qiu, Zengqi Yang, Ruyi Dang, Xinglong Wang. Emergency vaccination alleviates highly pathogenic porcine reproductive and respiratory syndrome virus infection after contact exposure. BMC Veterinary Research, 2013, 9:26
20、Jinquan Wang#, Xiao Li#, Xiaojing Yang, Qinwei Sun, Ruihua Huang, Jun Xing, Ruqian Zhao. Maternal dietary protein induces opposite myofiber type transition in Meishan pigs at weaning and finishing stages. Meat Science. 2011, 89: 221-227
21、Xiao Li, Xiaojing Yang, Bin Shan, Jian Shi, Dong Xia, J Wegner, Ruqian Zhao. Meat quality is associated with muscle metabolic status but not contractile myofiber type composition in premature pigs. Meat Science. 2009, 81: 218-223
六、联系方式
地址:陕西杨凌西农路22号 西北农林科技大学动物科技学院
电话:029-87081531
邮箱:nice.lixiao@gmail.com;nicelixiao@nwsuaf.edu.cn
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