王焕岭（女），华中农业大学教授，鱼类育种专家

　　王焕岭（女），华中农业大学教授。研究方向：分子遗传与鱼类育种。

一、教育简历

　　2001/09-2006/06，华中农业大学动物科技学院，动物遗传育种与繁殖，博士
　　1997/09-2001/06，河北农业大学动物科技学院，畜牧，学士

二、工作简历

　　2019/12 – 至今，华中农业大学，水产学院，教授
　　2012/05 – 2013/06，美国哈佛大学，医学院，访问学者
　　2011/01 – 至今，华中农业大学，水产学院，博士生导师
　　2009/01 – 2019/11，华中农业大学，水产学院，副教授
　　2006/07 – 2008/12，华中农业大学，水产学院，讲师

三、教学成果

　　指导的本科生获得湖北省优秀学士论文3篇；
　　指导的本科生获得第十二届“挑战杯”全国大学生课外学术科技作品竞赛二等奖1项
　　指导的研究生湖北省和校级优秀硕士论文共3篇；

四、科研项目

　　1、国家自然科学基金面上项目，低氧胁迫下团头鲂miR-462-731介导的Akt-FoxO通路在调控线粒体功能中的作用机制，2019-2022
　　2、广西科技重大专项，广西主导（特色）水产种质资源的收集、评价与鉴定，2017-2021
　　3、广西水产遗传育种与健康养殖重点实验室开放基金，miRNA在凡纳滨对虾氨氮适应中的功能研究，2017-2018
　　4、中央高校专项基金，2662015PY205，鱼类特异的miR-462-731簇在低氧调节中的作用机制，2016-2017
　　5、留学回国人员科研启动基金，miR-462/731簇在HIF-1α介导的低氧调节中的作用及功能，2015-2016
　　6、中央高校专项基金，2013PY067，团头鲂耐低氧性状优良品系选育研究，2013-2015
　　7、教育部新世纪优秀人才计划项目，2010年，水产
　　8、国家自然科学基金青年项目，RNA干扰沉默HIF-1在几种鱼类低氧调节中的分子机理研究，2010-2012
　　9、国际科学基金（IFS），Population structure and genetic diversity of Chinese sucker in the Yangzte river basin，2009-2011

五、科研论文

　　1、Huang CX, Huang Y, Duan XK, Zhang M, Tu JP, Liu JX, Liu H, Chen TS, Wang WM, Wang HL. Zebrafish miR-462-731 regulates hematopoietic specification and pu.1-dependent primitive myelopoiesis. Cell Death Differ. 2018 Nov 20. doi: 10.1038/s41418-018-0234-0 (IF:8.0) 　　2、Chen N, Huang CX, Huang CH, He Y, Chen TS, Zhu DM, Liu H, Wang WM, Wang HL. The molecular characterization, expression pattern and alternative initiation of Hif prolyl hydroxylase Phd1. Gene, 2018, 678: 219-225 (IF:2.415)
　　3、He Y, Huang CX, Chen N, Wu M, Huang Y, Liu H, Tang R, Wang WM, Wang HL.The zebrafish miR-125c is induced under hypoxic stress via hypoxia-inducible factor 1α and functions in cellular adaptations and embryogenesis.Oncotarget. 2017, 8 (43) : 73846-73859 (IF:5.165) 　　4、Chen N, Wu M, Wang HJ, Liu H, Wang WM, Wang HL. Effects of Acute Hypoxia and Reoxygenation on Physiological and Immune Responses and Redox Balance of Wuchang Bream (Megalobrama amblycephala Yih, 1955), Front. Physiol., 2017, 8:375 (IF:4.134)
　　5、Chen BX, Yi SK, Wang WF, He Y, Huang Y, Gao ZX, Liu H, Wang WM, Wang HL.Transcriptome comparison reveals insights into muscle response to hypoxia in blunt snout bream (Megalobrama amblycephala). Gene. 2017, 624:6-13. (IF:2.415) 　　6、Huang CX, Chen N, Wu XJ, He Y, Huang CH, Liu H, Wang WM, Wang HL. Zebrafish let-7b acts downstream of hypoxia-inducible factor-1α to assist in hypoxia-mediated cell proliferation and cell cycle regulation. Life Sciences, 2017, 171:21-29 (IF:2.936)
　　7、Huang CH, Chen N, Huang CX, Zhang B, Wu M, He L, Liu H, Tang R, Wang WM, Wang HL, Involvement of miR-462/731 cluster in hypoxia response in Megalobrama amblycephala. Fish Physiol Biochem, 2017, 43(3):863-873 (IF:1.647) 　　8、Wu M, Chen N, Huang CX, He Y, Zhao YZ, Chen XH, Chen XL, and Wang HL. Effect of Low Temperature on Globin Expression, Respiratory Metabolic Enzyme Activities, and Gill Structure of Litopenaeus vannamei. Biochemistry (Moscow), 2017, 82(7): 844-851 (IF:1.537) 　　9、Huang CX, Chen N, Wu XJ, Huang CH, He Y, Tang R, Wang WM, Wang HL. The zebrafish miR-462/miR-731 cluster is induced under hypoxic stress via hypoxia-inducible factor 1α and functions in cellular adaptations. FASEB J. 2015, 29(12): 4901-13 (IF:5.043)
　　10、Chen N, Wang WM, Wang HL. An efficient full-length cDNA amplification strategy based on bioinformatics technology and multiplexed PCR methods. Sci Rep, 2016，5:19420. (IF:5.578) 　　11、Zhang B, Chen N, Huang CH, Huang CX, Chen BX, Liu H, Wang WM, Wang HL, Molecular response and association analysis of Megalobrama amblycephala fih-1 with hypoxia, Mol Genet Genomics, 2016, 291(4): 1615-24 (IF: 2.728)
　　12、Chen N, Huang CH, Liu H, Chen BX, Wang WM, Wang HL. Alternative splicing transcription of Megalobrama amblycephala HIF prolyl hydroxylase PHD3 and up-regulation of PHD3 by HIF-1α. Biochem Biophys Res Commun, 2016, 469(3): 737-42. (IF:2.297) 　　13、Wang HJ, Huang CX, Chen N, Zhu KC, Chen BX, Wang WM, Wang HL. Molecular characterization and mRNA expression of HIF-prolyl hydroxylase-2 (phd2) in hypoxia-sensing pathways from Megalobrama amblycephala. Comp Biochem Physiol B Biochem Mol Biol. 2015, 186:28-35 (IF:1.551)
　　14、Zhu KC, Yu DH, Zhao JK, Wang WM, Wang HL. Morphological analysis and muscle-associated gene expression during different muscle growth phases of Megalobrama amblycephala. Genet Mol Res. 2015, 14(3):11639-51. (IF:0.775) 　　15、Xu MX, Huang CX, Chen N, Wu XJ, Zhu KC,Wang WM, Wang HL, Sequence analysis and expression regulation of rbp4 by 9-cis-RA in Megalobrama amblycephala, Fish Physiol Biochem. 2015, 41(2):437-47 (IF:1.622)
　　16、Chen N, Wan XL, Huang CX, Wang WM, Liu H, Wang HL. Study on the immune response to recombinant Hsp70 protein from Megalobrama amblycephala, Immunobiology, 2014, 219, 850–858 (IF:3.044) 　　17、Zhang J, Wei XL, Chen LP, Chen N, Xu MX, Huang C, Wang WM, Wang HL. Characterization of a novel CC chemokine CCL4 in immune response induced by nitrite and its expression differences among three populations of Megalobrama amblycephala. Fish & shellfish immunology. 2014, 38(1), 88-95 (IF:2.674)
　　18、Zhu KC, Wang HL, Wang HJ, Yasmeen Gul, Yang M, Zeng C, Wang WM, Characterization of muscle morphology and satellite cells, and expression of muscle-related genes in skeletal muscle of juvenile and adult Megalobrama amblycephala, Micron, 2014, 64, 66–75 (IF:1.988) 　　19、Zhu KC, Chen LP, Zhao JK, Wang HJ, Wang WM, Li Z, Wang HL.Molecular characterization and expression patterns of myogenin in compensatory growth of Megalobrama amblycephala.Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology. 2014,170, 10–17 (IF:1.551)
　　20、Huang CX, Wei XL, Chen N, Zhang J, Chen LP, Wang WM, Li JY, Wang HL.Growth differentiation factor 9 of Megalobrama amblycephala: molecular characterization and expression analysis during the development of early embryos and growing ovaries. Fish Physiol Biochem. 2014, 40(1):193-203 (IF:1.622) 　　21、Zhang J, Wei XL, Chen LP, Chen N, Li YH, Wang WM, Wang HL.Sequence analysis and expression differentiation of chemokine receptor CXCR4b among three populations of Megalobrama amblycephala, Dev Comp Immunol, 2013, 40(2):195-201 (IF:3.705)
　　22、Chen LP, Zhang J, Wei XL, Chen N, Huang CX, Xu MX, Wang WM, Wang HL.Megalobrama amblycephala cardiac troponin T variants: Molecular cloning, expression and response to nitrite. Gene, 2013, 527(2):558-64 (IF:2.082) 　　23、Liu SS, Zhu KC, Chen N, Wang WM, Wang HL.Identification of HIF-1α promoter and expression regulation of HIF-1α gene by LPS and hypoxia in zebrafish,Fish Physiol Biochem, 2013, 39(5):1153-63 (IF:1.676)
　　24、Chen N, Chen LP, Zhang J, Chen C, Wei XL, Gul Y, Wang WM, Wang HL,Molecular cloning, characterization and expression analysis of three hypoxia inducible factor alpha subunits, HIF-1α, HIF-2α and HIF-3α of the endangered hypoxia-sensitive freshwater species, Myxocyprinus asiaticus, Gene, 2012,498, 81-90 (IF:2.341) 　　25、Zhu KC, Wang HL, Gul Y, Zhao YH, Wang WM, Liu SS, Expression characterization and the promoter activity analysis of zebrafish hdac4,Fish Physiol Biochem, 2012, 38(2), 585-93 (IF:1.545)
　　26、Chen N, Wang WM, Wang HL.Isolation of polymorphic microsatellite loci from an endangered freshwater species Chinese sucker, Myxocyprinus asiaticus,Conserv Genet Resour, 2010, 2, 73–75 (IF:1.255) 　　27、Zhu KC, Wang WM, Yan BL, Gul Y, Wang HL.Development of polymorphic microsatellite markers for the swimming crab, Portunus trituberculatus (Miers, 1876), Conserv Genet Resour, 2010, 2, 117–119 (IF:1.255)
　　28、韦新兰，张杰，陈丽萍，王卫民，高泽霞，王焕岭＊，团头鲂SPATA4基因的分子克隆及表达分析，华中农业大学学报，2013, 32, 99-104
　　29、吴鑫杰，陈楠，黄春筱，王慧娟，王卫民，王焕岭＊. 低氧对团头鲂心肌细胞凋亡及抗氧化酶活性的影响，华中农业大学学报，2016,35(3):108-113