安磊,中国农业大学教授,家畜胚胎发育专家。
一、研究方向
以建立家畜配子胚胎高效利用技术为目标,主要研究家畜配子和胚胎发育调控机制,重点关注体外受精(IVF)胚胎发育异常的表观调控机制,突破家畜体外胚胎生产的关键技术瓶颈。
二、教授课程
本科:动物繁殖学实验
硕士:动物繁殖与胚胎工程技术实践、动物分子繁殖与发育理论、动物分子繁殖与发育理论。
三、学习简历
2000.09-2004.06:山西农业大学动物科技学院,获农学学士学位;
2004.09-2010.06:中国农业大学动物科技学院,获农学博士学位。
四、工作简历
2010.07-2013.12:中国农业大学,动物科技学院,讲师;
2014.01-2018.11:中国农业大学,动物科技学院,副教授,硕士生导师。
2018.11-至今: 中国农业大学,动物科技学院,教授。
五、社会兼职
畜牧兽医学会繁殖学分会理事;
《畜牧兽医杂志》、《畜牧兽医学报》、Reproduction in Domestic Animals、Journal of Integrative Agriculture审稿人。
六、科研项目
1、自然基金面上项目“C型钠肽在腔前卵泡成腔启动中的关键作用研究”(主持)2017.01-2020.12
2、“863”课题“羊重要经济性状功能基因组学研究”(主持子课题)2013.01-2017.12
3、支撑计划课题“猪牛繁殖障碍控制”(主持子课题),2011.01-2014.12
4、“863”课题“动物胚胎表观修饰及体细胞克隆技术研究”课题(参加),2011.01-2015.12
5、国家自然基金面上项目,体外胚胎出生性别比例失衡的分子机制研究(参加)2015.01-2018.12
七、论文( # 第一作者, * 通讯作者)
1、Tan K, An L#, Miao K, Ren L, Hou Z, Tao L, Zhang Z, Wang X, Xia W, Liu J, Wang Z, Xi G, Gao S, Sui L, Zhu DS, Wang S, Wu Z, Bach I, Chen DB, Tian J. Impaired imprinted X chromosome inactivation is responsible for the skewed sex ratio following in vitro fertilization. Proc Natl Acad Sci U S A 2016; 113: 3197-3202 (co-first author)
2、Tan K., Wang X., Zhang Z., Miao K., Yu Y., An L., and Tian JH., Downregulation of miR-199a-5p Disrupts the Developmental Potential of In Vitro-Fertilized Mouse Blastocysts. Biol Reprod (2016, in press online)
3、Tan K, Wang Z, Zhang Z, An L, Tian JH. IVF affects embryonic development in a sex-biased manner in mice. Reproduction 2016; 151:443-53.
4、L. Tao, M. Yang, X. Wang, Z. Zhang, Z. Wu, J. Tian, L. An , and S. Wang, Efficient biallelic mutation in porcine parthenotes using a CRISPR-Cas9 system. Biochem Biophys Res Commun 476 (2016) 225-9.
5、Tan K, Zhang Z, Miao K, Yu Y, Sui L, Tian J, An L. Dynamic integrated analysis of DNA methylation and gene expression profiles in in vivo and in vitro fertilized mouse post-implantation extraembryonic and placental tissues. Mol Hum Reprod 2016. 22; 485-98 6、Wei X, Xiaoling Z, Kai M, Rui W, Jing X, Min G, Zhonghong W, Jianhui T, Xinyu Z, Lei A. Characterization and comparative analyses of transcriptomes for in vivo and in vitro produced peri-implantation conceptuses and endometria from sheep. J Reprod Dev 2016.
7、Sui L, An L#, Tan K, Wang Z, Wang S, Miao K, Ren L, Tao L, He S, Yu Y, Nie J, Liu Q, Xing L, Wu Z, Hou Z, Tian J. Dynamic proteomic profiles of in vivo- and in vitro-produced mouse postimplantation extraembryonic tissues and placentas. Biol Reprod 2014; 91: 155.(co-first author) 8、Nie J, An L#, Miao K, Hou Z, Yu Y, Tan K, Sui L, He S, Liu Q, Lei X, Wu Z, Tian J. Comparative analysis of dynamic proteomic profiles between in vivo and in vitro produced mouse embryos during postimplantation period. J Proteome Res 2013; 12: 3843-3856. (co-first author) 5
9、Wang, Y., Wang, C., Hou, Z., Miao, K., Zhao, H., Wang, R., Guo, M., Wu, Z., Tian, J., An, L., 2013. Comparative analysis of proteomic profiles between endometrial caruncular and intercaruncular areas in ewes during the peri-implantation period. J Anim Sci Biotechnol 4, 39. 2 10、Pang YW, An L#, Wang P, Yu Y, Yin QD, Wang XH, Xin-Zhang, Qian-Zhang, Yang ML, Min-Guo, Wu ZH, Tian JH. Treatment of porcine donor cells and reconstructed embryos with the antioxidant melatonin enhances cloning efficiency. J Pineal Res 2013; 54: 389-397. (co-first author) 5
11、An L#, Pang YW, Gao HM, Tao L, Miao K, Wu ZH, Tian JH. Heterologous expression of C. elegans fat-1 decreases the n-6/n-3 fatty acid ratio and inhibits adipogenesis in 3T3-L1 cells. Biochem Biophys Res Commun 2012; 428: 405-410. 3
12、Ma W, An L#, Wu Z, Wang X, Guo M, Miao K, Ma W, Tian J. Efficient and safe recipient preparation for transplantation of mouse spermatogonial stem cells: pretreating testes with heat shock. Biol Reprod 2011; 85: 670-677. (co-first author) 10 13、An L#, Wu ZH, Wu YF, Zhang XL, Liu X, Zhu YB, Cheng WM, Gao HM, Guo M, Tian JH. Fertility in single-ovulating and superovulated dairy heifers after insemination with low dose sex-sorted sperm. Reprod Domest Anim 2010; 45: e344-e350. 9
14、Cheng WM, An L#, Wu ZH, Zhu YB, Liu JH, Gao HM, Li XH, Zheng SJ, Chen DB, Tian JH*. Effects of disulfide bond reducing agents on sperm chromatin structural integrity and developmental competence of in vitro matured oocytes after intracytoplasmic sperm injection in pigs. Reproduction 2009; 137: 633-643. (co-first author) 9
八、专利
1、Method for inducing twin calving. US 20140349934A1 (国际发明专利)
2、C型钠肽在促进牛卵母细胞体外成熟中的应用 ZL201210348285.9
3、来曲唑在用于制备成年牛超数排卵药物中的应用 ZL201110436200.8
4、来曲唑在制备激素诱导犊牛卵泡发育药物中的应用 ZL201110434833.5
5、一种猪用子宫深部低剂量输精器械及其输精器的端部探伸构造ZL201220721931.7
6、一种制备奶牛性别控制精子的方法 ZL201110059938.7
7、一种消化卵母细胞透明带的方法 ZL200610012029.7
九、奖励荣誉
1、2011年参与专业硕士学位课“动物繁殖技术进展与实践”课程建设,获校级优秀课程;
2、2013年参与“家畜繁殖学”课程建设,获国家级精品资源共享课;
3、2010-2014担任动科102班班主任,班级先后获得 “北京市先进班集体”、校级“优良学风班” 、“优秀团支部”等称号;
4、2014年指导本科毕业设计获得校级优秀论文;
5、2015年学院优秀党员;
6、2016年“大北农青年学者奖”。
十、联系方式
地址:北京市海淀区圆明园西路2号
电话:010-62734627
邮箱:anleim@cau.edu.cn
发布者:猪倌,转转请注明出处:https://www.yzydt.com/3742/
评论列表(2条)
[…] 数量遗传学、生物信息学理论和计算技术研究;基于多组学信息进行畜禽复杂性状遗传机理解析;以猪和奶牛为对象进行常规育种和组学相结合的研究。 教授推荐:安磊,中国农业大学教授,家畜胚胎发育专家 […]
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